THC-O Acetate is a synthetic cannabinoid that has been found in products sold as legal highs. It was first identified in 2013 in a product called “K2 Summit.” THC-O Acetate is a potent agonist of the cannabinoid receptor 1 (CB1) and has been shown to produce psychoactive effects similar to those produced by Δ9-tetrahydrocannabinol, or ∆9-THC. The drug acts at CB1 receptors located throughout the body, including within the brain, where it produces its primary effect on mood and cognition. In addition to acting as an agonist for CB1 receptors, THC-O acetate also binds with high affinity to opioid μ-opioid receptors; this binding may contribute to some of its pharmacological properties, such as sedation.
Methods:
This open-label phase 1 trial recruited 18 participants who were given an escalating dose of THC-O acetate via mouthpiece over 10 minutes. Blood samples were taken at baseline and up to 6 hours after administration for analysis of plasma concentrations using liquid chromatography-tandem mass spectrometry. Pharmacokinetic parameters including maximum concentration Cmax, area under the curve AUC from time zero to infinity AUCinfinity, half-life t1/2, apparent volume of distribution Vd, clearance Cl and peak time Tmax were calculated by noncompartmental methods. Safety was assessed throughout the study period using clinical laboratory tests, vital signs measurements, and adverse events monitoring. Plasma concentrations of naltrexone increased rapidly following oral dosing with a median Tmax value of 1 hour and reached a steady-state within 3 days. Naltrexone showed linear pharmacokinetics in healthy volunteers. The mean bioavailability was 99% +/- 7%.
Results:
The mean age of subjects was 26 years with a range of 21–32 years
THC-O Acetate is a newly synthesized cannabinoid that is currently being researched for its potential therapeutic benefits. This cannabinoid is a derivative of THC, and it is thought to be more potent and longer-lasting than THC. So far, THC-O Acetate has been shown to be effective in treating pain, inflammation, and anxiety. It is also believed to be non-addictive and safe for long-term use. However, the safety profile of this compound remains unknown at present
Effects:
THC-O Acetate is a potent agonist of the CB1 receptor and produces psychoactive effects that are similar to those of THC. It has been used as an experimental drug in studies on cannabis, but its use for recreational purposes remains controversial due to a lack of safety data. The main side effect reported with this compound was dizziness. Many people ask where to buy THC-Acetate.
Pharmacology:
THC-O Acetate is a synthetic cannabinoid that is structurally similar to THC. This substance acts as both an agonist at the CB1 receptors and an antagonist at the GPR55 receptor. In animal models, it induces hypothermia via activation of TRPV1 channels, which are expressed in peripheral sensory neurons. It also produces analgesia by activating spinal cord opioid receptors. The effects of this drug appear to be mediated through direct binding to these sites rather than indirect mechanisms such as inhibition of endocannabinoid reuptake or antagonism of other cannabinoids like CBD.
Toxicity:
THC-O Acetate is a synthetic cannabinoid that has recently been discovered in herbal incense products. It is a potent agonist of the cannabinoid receptor and its effects are similar to those of THC. Little is known about this compound at this time, but it is thought to be more potent than THC. THC-O Acetate is toxic and can cause serious health problems if ingested. Symptoms include nausea, vomiting, diarrhea, mental confusion, seizures, hallucinations, coma, and death. There have also been reports of psychosis, paranoia, anxiety, aggression, agitation, insomnia, tremors, muscle spasms, and convulsions after ingestion of this substance
1. THC-O Acetate is a synthetic cannabinoid that is similar to THC.
2. It is a Schedule I drug in the United States and is illegal.
3. THC-O Acetate has been linked to numerous overdoses and deaths.
4. It is often sold as a “legal high” and can be very dangerous.
5. The Drug Enforcement Administration is working to ban it nationwide.
conclusion:
THC-O Acetate is a cannabinoid that is found in cannabis. This cannabinoid is not as well known as THC, but it is thought to have similar effects. THC-O Acetate is thought to be a psychoactive cannabinoid, meaning that it can cause the user to feel high. This cannabinoid is also believed to have medical benefits, and research into its potential benefits is ongoing.